Which patients may present with PAH?

Once thought to be a disease of young women, PAH is now known to affect both genders and all age groups.1

Associate Professor Eugene Kotlyar

Patients on high risk to develop PAH

Associate Professor Eugene Kotlyar

70-80%

of PAH patients
are female2

iPAH mean age at diagnosis is

50-65 years2

3 out of 4

PAH patients are in WHO FC III-IV at the time of diagnosis3

Example cases* of patients presenting with PAH

*Examples for illustrative purposes only. Not based on actual patients.

Remember, if you see unexplained breathlessness similar to the cases above, Suspect PH.

References
  1. McGoon MD, et al. J Am Coll Cardiol 2013; 62(25 Suppl):D51-5.
  2. Hoeper MM and Gibbs JSR. Eur Respir Rev 2014; 23:450–7.
  3. Humbert M, et al. Am J Respir Crit Care Med 2006; 173:1023–30.
  4. McLaughlin VV, et al. J Am Coll Cadiol 2009; 53:1573–619.
Footnotes
FC=functional class; iPAH=idiopathic PAH; PAH=pulmonary arterial hypertension; SSc=systemic sclerosis; WHO=World Health Organization.

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World Health Organization functional class (WHO-FC) for patients with PH3,5

This system grades PH severity according to the patient’s functional status, by linking symptoms with activity limitations. WHO-FC remains a powerful predictor of outcomes in patients with PAH.

WHO - FC Description
I
Patients with PH in whom there is no limitation of usual physical activity; ordinary physical activity does not cause increased dyspnoea, fatigue, chest pain, or presyncope.
II
Patients with PH who have mild limitation of physical activity. There is no discomfort at rest, but normal physical activity causes increased dyspnoea, fatigue, chest pain, or presyncope.
III
Patients with PH who have a marked limitation of physical activity. There is no discomfort at rest, but less than ordinary activity causes increased dyspnoea, fatigue, chest pain, or presyncope.
IV
Patients with PH who are unable to perform any physical activity at rest and who may have signs of right ventricular failure. Dyspnoea and/or fatigue may be present at rest, and symptoms are increased by almost any physical activity.
Adapted from McGoon M, et al. 2004.5
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